Knockdown of HMGN5 in Induces Cell Cycle Arrest in Human Lung Cancer

Lung cancer is the leading cause of cancer death worldwide (Jemal et al., 2006). Despite surgical resection and advances in radiotherapy and chemotherapy, long-term survival rates remain extremely poor over the past years (Spiro and Silvestri, 2005). It has been established that lung cancer arises as a consequence of the accumulation of multiple genetic alterations involving critical genes that control cell proliferation and survival (Minna et al., 2002; Osada and Takahashi, 2002). Therefore, a better understanding of oncogenic signaling mechanism underlying lung cancer and the identification of new therapeutic targets for treatment of this disease are urgently needed. High mobility group nucleosome-binding (HMGN) protein family contains five architectural non-histone chromosomal proteins, which specifically binds to the nucleosome core particle (CP) by their nucleosomal binding domain (NBD) in a sequence-independent manner and modulate the structure and function of chromatin (Bustin, 1999; Postnikov and Bustin, 2010; Zhu and